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Journal of Clinical Microbiology, January 2001, p. 385-388, Vol. 39, No. 1
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.1.385-388.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparison of In Vitro Activities of Voriconazole and Five Established Antifungal Agents against Different Species of Dermatophytes Using a Broth Macrodilution Method

Sofia Perea,1,* Annette W. Fothergill,1 Deanna A. Sutton,1 and Michael G. Rinaldi1,2

Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7881,1 and Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78284-77502

Received 13 July 2000/Returned for modification 25 August 2000/Accepted 6 November 2000

The in vitro activities of voriconazole against 19 different species of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, griseofulvin, and fluconazole. MICs were determined according to a National Committee for Clinical Laboratory Standards broth macrodilution method. Voriconazole appeared more active than ketoconazole, griseofulvin, and fluconazole and less active than itraconazole and terbinafine. Based on these results, voriconazole merits further investigation as a potentially useful agent for the treatment of dermatophytosis.

* Corresponding author. Mailing address: Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., Mail code 7881, San Antonio, TX 78229-3900. Phone: (210) 567-1981. Fax: (210) 567-3303. E-mail: PEREA{at}UTHSCSA.EDU.

Journal of Clinical Microbiology, January 2001, p. 385-388, Vol. 39, No. 1
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.1.385-388.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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