This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kalach, N.
Right arrow Articles by Raymond, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kalach, N.
Right arrow Articles by Raymond, J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, January 2001, p. 394-397, Vol. 39, No. 1
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.1.394-397.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

High Levels of Resistance to Metronidazole and Clarithromycin in Helicobacter pylori Strains in Children

Nicolas Kalach,1 Michel Bergeret,2 Pierre Henri Benhamou,1 Christophe Dupont,1 and Josette Raymond2,*

Department of Pediatrics, Division of Pediatric Gastroenterology & Nutrition,1 and Department of Microbiology,2 Hôpital Saint Vincent de Paul, Université Paris V-René Descartes, 75674 Paris Cedex 14, France

Received 22 December 1999/Returned for modification 5 April 2000/Accepted 23 October 2000

The aim of the study was to evaluate the prevalence of resistance to amoxicillin, metronidazole, and clarithromycin before treatment of Helicobacter pylori infection in children and to assess the evolution of resistance with time. The study was carried out between 1994 and 1999 with 150 H. pylori-positive children through gastric culture (antimicrobial susceptibility) and histology. All cultured H. pylori strains were sensitive to amoxicillin, 64 (43%) were resistant to metronidazole, 32 (21%) were resistant to clarithromycin, and 14 (9%) were resistant to both metronidazole and clarithromycin. The overall prevalence of resistance to metronidazole and clarithromycin did not change significantly with time. The study highlights the generalized high-level and stable metronidazole and clarithromycin resistance of H. pylori strains from children.

* Corresponding author. Mailing address: Service de Bactériologie, Hôpital Saint Vincent de Paul, 82, Avenue Denfert Rochereau, 75674 Paris Cedex 14, France. Phone: 33 1 40 48 82 42. Fax: 33 1 40 48 83 18. E-mail: j.raymond{at}svp.ap-hop-paris.fr.

Journal of Clinical Microbiology, January 2001, p. 394-397, Vol. 39, No. 1
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.1.394-397.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Boyanova, L., Nikolov, R., Lazarova, E., Gergova, G., Katsarov, N., Kamburov, V., Spassova, Z., Derejian, S., Jelev, C., Mitov, I., Krastev, Z. (2006). Antibacterial resistance in Helicobacter pylori strains isolated from Bulgarian children and adult patients over 9 years. J Med Microbiol 55: 65-68 [Abstract] [Full Text]  
  • Kato, S., Sherman, P. M. (2005). What Is New Related to Helicobacter pylori Infection in Children and Teenagers?. Arch Pediatr Adolesc Med 159: 415-421 [Abstract] [Full Text]  
  • Kim, J. M., Kim, J. S., Jung, H. C., Kim, N., Kim, Y.-J., Song, I. S. (2004). Distribution of Antibiotic MICs for Helicobacter pylori Strains over a 16-Year Period in Patients from Seoul, South Korea. Antimicrob. Agents Chemother. 48: 4843-4847 [Abstract] [Full Text]  
  • Megraud, F (2004). H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 53: 1374-1384 [Full Text]  
  • Boyanova, L., Gergova, G., Koumanova, R., Jelev, C., Lazarova, E., Mitov, I., Kovacheva, Y. (2004). Risk factors for primary Helicobacter pylori resistance in Bulgarian children. J Med Microbiol 53: 911-914 [Abstract] [Full Text]  
  • Taneike, I., Suzuki, K., Nakagawa, S., Yamamoto, T. (2004). Intrafamilial Spread of the Same Clarithromycin-Resistant Helicobacter pylori Infection Confirmed by Molecular Analysis. J. Clin. Microbiol. 42: 3901-3903 [Abstract] [Full Text]  
  • Falsafi, T., Mobasheri, F., Nariman, F., Najafi, M. (2004). Susceptibilities to Different Antibiotics of Helicobacter pylori Strains Isolated from Patients at the Pediatric Medical Center of Tehran, Iran. J. Clin. Microbiol. 42: 387-389 [Abstract] [Full Text]  
  • Alarcon, T., Vega, A. E., Domingo, D., Martinez, M. J., Lopez-Brea, M. (2003). Clarithromycin Resistance among Helicobacter pylori Strains Isolated from Children: Prevalence and Study of Mechanism of Resistance by PCR-Restriction Fragment Length Polymorphism Analysis. J. Clin. Microbiol. 41: 486-499 [Abstract] [Full Text]  
  • BOYANOVA, L., KOUMANOVA, R., GERGOVA, G., POPOVA, M., MITOV, I., KOVACHEVA, Y., DEREJIAN, S., KATSAROV, N., NIKOLOV, R., KRASTEV, Z. (2002). Prevalence of resistant Helicobacter pylori isolates in Bulgarian children. J Med Microbiol 51: 786-790 [Abstract] [Full Text]  
  • Kato, S., Fujimura, S., Udagawa, H., Shimizu, T., Maisawa, S., Ozawa, K., Iinuma, K. (2002). Antibiotic Resistance of Helicobacter pylori Strains in Japanese Children. J. Clin. Microbiol. 40: 649-653 [Abstract] [Full Text]  
  • Kalach, N., Benhamou, P. H., Dupont, C., Raymond, J., Bergeret, M., Gottrand, F., Husson, M. O. (2001). Helicobacter pylori in Children: Acquisition of Antimicrobial Resistance after an Initial Course of Treatment. J. Clin. Microbiol. 39: 3018-3019 [Full Text]  
  • Torres, J., Camorlinga-Ponce, M., Perez-Perez, G., Madrazo-De la Garza, A., Dehesa, M., Gonzalez-Valencia, G., Munoz, O. (2001). Increasing Multidrug Resistance in Helicobacter pylori Strains Isolated from Children and Adults in Mexico. J. Clin. Microbiol. 39: 2677-2680 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»