This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chomel, B. B.
Right arrow Articles by Kittleson, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chomel, B. B.
Right arrow Articles by Kittleson, M. D.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, October 2001, p. 3548-3554, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3548-3554.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Aortic Valve Endocarditis in a Dog Due to Bartonella clarridgeiae

Bruno B. Chomel,1,* Kristin A. Mac Donald,2 Rickie W. Kasten,1 Chao-Chin Chang,1 Aaron C. Wey,2 Janet E. Foley,3 William P. Thomas,2 and Mark D. Kittleson2

Department of Population Health and Reproduction,1 Cardiology Unit, Veterinary Medical Teaching Hospital and Department of Medicine and Epidemiology,2 and Center for Companion Animal Health,3 School of Veterinary Medicine, University of California, Davis, California 95616

Received 20 February 2001/Returned for modification 8 May 2001/Accepted 29 May 2001

We report the first documented case of endocarditis associated with Bartonella clarridgeiae in any species. B. clarridgeiae was identified as a possible etiological agent of human cat scratch disease. Infective vegetative valvular aortic endocarditis was diagnosed in a 2.5-year-old male neutered boxer. Historically, the dog had been diagnosed with a systolic murmur at 16 months of age and underwent balloon valvuloplasty for severe valvular aortic stenosis. Six months later, the dog was brought to a veterinary hospital with an acute third-degree atrioventricular block and was diagnosed with infective endocarditis. The dog died of cardiopulmonary arrest prior to pacemaker implantation. Necropsy confirmed severe aortic vegetative endocarditis. Blood culture grew a fastidious, gram-negative organism 8 days after being plated. Phenotypic and genotypic characterization of the isolate, including partial sequencing of the citrate synthase (gltA) and 16S rRNA genes indicated that this organism was B. clarridgeiae. DNA extraction from the deformed aortic valve and the healthy pulmonic valve revealed the presence of B. clarridgeiae DNA only from the diseased valve. No Borrelia burgdorferi or Ehrlichia sp. DNA could be identified. Using indirect immunofluorescence tests, the dog was seropositive for B. clarridgeiae and had antibodies against Ehrlichia phagocytophila but not against Ehrlichia canis, Ehrlichia ewingii, B. burgdorferi, or Coxiella burnetii.

* Corresponding author. Mailing address: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616. Phone: (530) 752-8112. Fax: (530) 752-2377. E-mail: bbchomel{at}ucdavis.edu.

Journal of Clinical Microbiology, October 2001, p. 3548-3554, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3548-3554.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Koehler, J. E., MacDonald, K. A., Kittleson, M. D., Thomas, W. P., Chomel, B. B. (2009). Infective Endocarditis in a Dog and the Phylogenetic Relationship of the Associated "Bartonella rochalimae" Strain with Isolates from Dogs, Gray Foxes, and a Human. J. Clin. Microbiol. 47: 787-790 [Abstract] [Full Text]  
  • Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Theis, J. H., Foley, J. E., Chomel, B. B. (2007). Gray Foxes (Urocyon cinereoargenteus) as a Potential Reservoir of a Bartonella clarridgeiae-Like Bacterium and Domestic Dogs as Part of a Sentinel System for Surveillance of Zoonotic Arthropod-Borne Pathogens in Northern California. J. Clin. Microbiol. 45: 2411-2418 [Abstract] [Full Text]  
  • Pesavento, P. A., Chomel, B. B., Kasten, R. W., McDonald, K. A., Mohr, F. C. (2005). Pathology of Bartonella Endocarditis in Six Dogs. Vet Pathol 42: 370-373 [Abstract] [Full Text]  
  • Breitschwerdt, E. B., Blann, K. R., Stebbins, M. E., Munana, K. R., Davidson, M. G., Jackson, H. A., Willard, M. D. (2004). Clinicopathological Abnormalities and Treatment Response in 24 Dogs Seroreactive to Bartonella vinsonii (berkhoffii) Antigens. Journal of the American Animal Hospital Association 40: 92-101 [Abstract] [Full Text]  
  • Chomel, B. B., Wey, A. C., Kasten, R. W. (2003). Isolation of Bartonella washoensis from a Dog with Mitral Valve Endocarditis. J. Clin. Microbiol. 41: 5327-5332 [Abstract] [Full Text]  
  • Chomel, B. B., Wey, A. C., Kasten, R. W., Stacy, B. A., Labelle, P. (2003). Fatal Case of Endocarditis Associated with Bartonella henselae Type I Infection in a Domestic Cat. J. Clin. Microbiol. 41: 5337-5339 [Abstract] [Full Text]  
  • Mexas, A. M., Hancock, S. I., Breitschwerdt, E. B. (2002). Bartonella henselae and Bartonella elizabethae as Potential Canine Pathogens. J. Clin. Microbiol. 40: 4670-4674 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»