This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Goto, K. Articles by Itoh, T. Search for Related Content PubMed PubMed Citation Articles by Goto, K. Articles by Itoh, T.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, October 2001, p. 3703-3704, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3703-3704.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Contamination of Transplantable Human Tumor-Bearing Lines by Helicobacter hepaticus and Its Elimination

Kazuo Goto,^1,* Ken-Ichi Ishihara,^1,2 Ayako Kuzuoka,¹ Yasuyuki Ohnishi,¹ and Toshio Itoh¹

Central Institute for Experimental Animals, Miyamae-ku, Kawasaki, Kanagawa 216-0001,¹ and J. A. C. Inc., Aobadai, Meguroku 153-0042,² Japan

Received 24 May 2001/Returned for modification 2 July 2001/Accepted 23 July 2001

Helicobacter hepaticus contaminating nonfrozen tumors was transmissible to severe combined immunodeficient (SCID) mice, but the organism in cryopreserved samples was not. This suggests that H. hepaticus has the ability to spread via biomaterials and that freezing-thawing is able to reduce the numbers of organisms to levels insufficient for subcutaneous infection of SCID mice.

---

^* Corresponding author. Mailing address: Central Institute for Experimental Animals, 1430 Nogawa, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan. Phone: 81-44-751-4477. Fax: 81-44-751-4476. E-mail: gotok{at}ciea.or.jp.

---

Journal of Clinical Microbiology, October 2001, p. 3703-3704, Vol. 39, No. 10
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.10.3703-3704.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.