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Journal of Clinical Microbiology, November 2001, p. 3920-3926, Vol. 39, No. 11
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.11.3920-3926.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Helicobacter typhlonius sp. nov., a Novel Murine Urease-Negative Helicobacter Species

Craig L. Franklin,1 Peter L. Gorelick,2 Lela K. Riley,1 Floyd E. Dewhirst,3 Robert S. Livingston,1 Jerrold M. Ward,4 Catherine S. Beckwith,1 and James G. Fox5,*

Research Animal Diagnostic and Investigative Laboratory, Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri 652111; Animal Health Diagnostic Laboratory, Laboratory Animal Sciences Program, NCI-FCRDC, Science Applications International Corporation, Frederick, Maryland 217012; Forsyth Institute, Boston, Boston, Massachusetts 021153; Veterinary and Tumor Pathology Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 021154; and Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 021395

Received 3 July 2001/Returned for modification 7 August 2001/Accepted 28 August 2001

Over the past decade, several Helicobacter species have been isolated from rodents. With the advent of PCR for the diagnosis of infectious agents, it has become clear that several previously uncharacterized Helicobacter species also colonize rodents. In this report, we describe a novel urease-negative helicobacter, Helicobacter typhlonius sp. nov., which was isolated from colonies of laboratory mice independently by two laboratories. Infection of immunodeficient mice by this bacterium resulted in typhlocolitis similar to that observed with other helicobacter infections. H. typhlonius is genetically most closely related to H. hepaticus. Like H. hepaticus, it is a spiral bacterium with bipolar sheathed flagella. However, this novel species contains a large intervening sequence in its 16S rRNA gene and is biochemically distinct from H. hepaticus. Notably, H. typhlonius does not produce urease or H2S nor does it hydrolize indoxyl-acetate. Compared to other Helicobacter species that commonly colonize rodents, H. typhlonius was found to be less prevalent than H. hepaticus and H. rodentium but as prevalent as H. bilis. H. typhlonius joins a growing list of helicobacters that colonize mice and are capable of inducing enteric disease in various strains of immunodeficient mice.

* Corresponding author. Mailing address: Division of Comparative Medicine, Massachusetts Institute of Technology, Bldg. 16-825C, 77 Massachusetts Ave., Cambridge, MA 02139-4307. Phone: (617) 253-1757. Fax: (617) 258-5708. E-mail: jgfox{at}mit.edu.

Journal of Clinical Microbiology, November 2001, p. 3920-3926, Vol. 39, No. 11
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.11.3920-3926.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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