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Journal of Clinical Microbiology, February 2001, p. 779-781, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.779-781.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nosocomial Spread of an Unusual Methicillin-Resistant Staphylococcus aureus Clone That Is Sensitive to All Non--Lactam Antibiotics, Including Tobramycin

Spyros Pournaras,^1,2 Aris Slavakis,¹ Aleka Polyzou,¹ Danai Sofianou,¹ Antonios N. Maniatis,² and Athanassios Tsakris^3,*

Department of Microbiology, Hippokration General Hospital,¹ and Department of Microbiology, Medical School, Aristotle University of Thessaloniki,³ Thessaloniki, and Department of Medical Microbiology, University of Thessalia, Larissa,² Greece

Received 28 September 2000/Returned for modification 6 November 2000/Accepted 21 November 2000

Between January and December 1999, in Hippokration General Hospital, Thessaloniki, Greece, a large proportion of the methicillin-resistant Staphylococcus aureus isolates (34.4%) exhibited susceptibility to virtually all alternative non--lactam antibiotics, including tobramycin. Twenty-five of them were selected randomly for further testing; all belonged to a unique genotype and were characterized as heterogeneously resistant to oxacillin. The aadD gene, encoding tobramycin resistance, failed to be amplified in all cases, indicating absence of the gene or the entire plasmid pUB110 from the mec DNA.

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^* Corresponding author. Mailing address: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece. Phone: 30 31 99 90 91. Fax: 30 31 99 91 49. E-mail: atsakris{at}med.auth.gr.

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Journal of Clinical Microbiology, February 2001, p. 779-781, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.779-781.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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