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Journal of Clinical Microbiology, February 2001, p. 798-800, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.798-800.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Relationship between Susceptibility to Hemolytic-Uremic Syndrome and Levels of Globotriaosylceramide in Human Sera

Shinobu Watarai,1 Kenji Yokota,2 Tana,1 Takumi Kishimoto,3 Tomohosa Kanadani,4 Kazuhisa Taketa,5 and Keiji Oguma2,*

Laboratory of Veterinary Immunology, Department of Veterinary Science, College of Agriculture, Osaka Prefecture University, Sakai, Osaka,1 Department of Bacteriology, Okayama University Medical School,2 Okayama Rosai Hospital,3 and Okayama National Hospital,4 Okayama, and Ibara City Hospital, Ibara,5 Japan

Received 19 May 2000/Returned for modification 24 August 2000/Accepted 9 November 2000

The relationship between differential susceptibility to hemolytic-uremic syndrome (HUS) and levels of globotriaosylceramide (Gb3) in serum was studied in patients infected with verotoxin-producing Escherichia coli (VTEC). The serum Gb3 levels in patients with HUS were lower than these in diarrheal patients without subsequent HUS or in patients without clinical symptoms, indicating that individuals with a lower content of serum Gb3 show a higher incidence of HUS following VTEC infection.

* Corresponding author. Mailing address: Department of Bacteriology, Okayama University Medical School, Shikata-cho, Okayama 700-8558, Japan. Phone: 81-86-235-7157. Fax: 81-86-235-7162. E-mail: kuma{at}med.okayama-u.ac.jp.

Journal of Clinical Microbiology, February 2001, p. 798-800, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.798-800.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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