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Journal of Clinical Microbiology, February 2001, p. 811-815, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.811-815.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Vancomycin-Resistant Enterococcus faecium Strain Carrying the vanB2 Gene Variant in a Polish Hospital

Magdalena Kawalec,1 Marek Gniadkowski,1 Urszula Zielinska,2 Waldemar Kłos,2 and Waleria Hryniewicz1,*

Sera & Vaccines Central Research Laboratory, 00-725 Warsaw,1 and Medical Center for Postgraduate Education, 00-416 Warsaw,2 Poland

Received 23 August 2000/Returned for modification 22 October 2000/Accepted 11 November 2000

About 2.5 years after the first isolation of the VanA phenotype of vancomycin-resistant Enterococcus faecium (VREM) in Poland, the first VREM strains with the VanB phenotype have emerged independently in two different Warsaw hospitals. In one of these the VREM strain was selected during the long-term antimicrobial treatment of a patient with a wide variety of infection risk factors who died after 3 months of hospitalization. The strain was found to contain the transferable vanB2 gene cluster variant of the polymorphic type that was identified earlier in vancomycin-resistant enterococci from several different countries. In the course of infection the strain underwent genetic diversification due to DNA recombination.

* Corresponding author. Mailing address: Sera & Vaccines Central Research Laboratory, ul. Chełmska 30/34, 00-725 Warsaw, Poland. Phone: (48) 22-841 33 67. Fax: (48) 22-841 29 49. E-mail: waleria{at}urania.il.waw.pl.

Journal of Clinical Microbiology, February 2001, p. 811-815, Vol. 39, No. 2
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.2.811-815.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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