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Journal of Clinical Microbiology, March 2001, p. 1134-1136, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.1134-1136.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Cutaneous Infection Caused by Aspergillus ustus, an Emerging Opportunistic Fungus in Immunosuppressed Patients

Josepa Gené,1,2,* Antoni Azón-Masoliver,3 Josep Guarro,1,2 Gabriel De Febrer,4 Angels Martínez,5 Cristina Grau,3 Montserrat Ortoneda,1,2 and Frederic Ballester6

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut,1 and Unitats de Dermatologia,3 Sociosanitària,4 Anatomia Patològica,5 and Microbiologia,6 Hospital Universitari de Sant Joan, and Institut d'Estudis Avançats,2 Universitat Rovira i Virgili, 43201-Reus, Tarragona, Spain

Received 17 July 2000/Returned for modification 22 August 2000/Accepted 22 September 2000

We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. The patient failed to respond to itraconazole and died before receiving a new treatment with amphotericin B. There have been eight other cases reported since 1973, and only two patients survived the infection. In vitro susceptibility testing of seven antifungal drugs showed that terbinafine and the new azole derivative UR-9825 were the most active against this fungus.

* Corresponding author. Mailing address: Unitat de Microbiologia, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201-Reus, Tarragona, Spain. Phone: 34 977759359. Fax: 34 977759322. E-mail: jgd{at}fmcs.urv.es.

Journal of Clinical Microbiology, March 2001, p. 1134-1136, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.1134-1136.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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