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Journal of Clinical Microbiology, March 2001, p. 1165-1168, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.1165-1168.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Possible Horizontal Transfer of the vanB2 Gene among Genetically Diverse Strains of Vancomycin-Resistant Enterococcus faecium in a Korean Hospital

Wee Gyo Lee,1,* John A. Jernigan,2 James K. Rasheed,3 Gregory J. Anderson,3 and Fred C. Tenover3

Department of Clinical Pathology, Ajou University School of Medicine, Suwon, Korea1; Division of Infectious Disease, Emory University School of Medicine, Atlanta, Georgia 303292; and Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia 303333

Received 18 September 2000/Returned for modification 11 November 2000/Accepted 11 December 2000

A total of 25 isolates of vanB-containing Enterococcus faecium were recovered from patients in a single Korean hospital over a 20-month period. There were two distinct vanB2 patterns among the 11 pulsed-field gel electrophoresis types; 17 contained the prototype vanB2 and 8 contained a novel vanB2 with a 177-bp deletion in vanYB. Both vanB2 genes were transmissible in vitro at a mean frequency of 1.1 × 10-8 transconjugants/donor. These results suggest the horizontal spread of vanB2 is occurring among genetically diverse strains of E. faecium in Korean hospitals.

* Corresponding author. Mailing address: Department of Clinical Pathology, Ajou University Hospital, San 5, Wonchun-Dong, Paldal-Gu, Suwon 442-749, South Korea. Phone: 82-31-219-5785. Fax: 82-31-219-5778. E-mail: weegyo{at}madang.ajou.ac.kr.

Journal of Clinical Microbiology, March 2001, p. 1165-1168, Vol. 39, No. 3
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.3.1165-1168.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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