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Journal of Clinical Microbiology, April 2001, p. 1580-1585, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1580-1585.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Isolation of Helicobacter cinaedi from the Colon, Liver, and Mesenteric Lymph Node of a Rhesus Monkey with Chronic Colitis and Hepatitis

J. G. Fox,1,* L. Handt,2 B. J. Sheppard,1 S. Xu,1 F. E. Dewhirst,3 S. Motzel,2 and H. Klein2

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 021391; Merck Research Laboratories, West Point, Pennsylvania 194682; and Forsyth Institute, Boston, Massachusetts 021153

Received 28 November 2000/Returned for modification 9 January 2001/Accepted 19 January 2001

On the basis of biochemical, phenotypic, and 16S rRNA analyses, Helicobacter cinaedi was isolated from the colon, liver, and mesenteric lymph nodes of a 2-year-old rhesus monkey with chronic diarrhea. Histologically, the liver had mild to moderate biliary hyperplasia and hypertrophy with periportal inflammation and fibrosis. Colonic and cecal lesions consisted of diffuse chronic inflammation and glandular hyperplasia extending the length of the crypts. This is the first observation of H. cinaedi associated with active hepatitis and colitis in a nonhuman primate.

* Corresponding author. Mailing address: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave., Bldg. 16, Rm. 825C, Cambridge, MA 02139. Phone: (617) 253-1757. Fax: (617) 253-5708. E-mail: jgfox{at}mit.edu.

Journal of Clinical Microbiology, April 2001, p. 1580-1585, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1580-1585.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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