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Journal of Clinical Microbiology, April 2001, p. 1612-1614, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1612-1614.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparison of Roche MONITOR and Organon Teknika NucliSens Assays To Quantify Human Immunodeficiency Virus Type 1 RNA in Cerebrospinal Fluid

Paul Spearman,^1,2,* Susan A. Fiscus,³ Rita M. Smith,¹ Robin Shepard,³ Benjamin Johnson,⁴ Janet Nicotera,⁵ Victoria L. Harris,⁵ Lisa A. Clough,⁵ Joel McKinsey,⁵ and David W. Haas^2,5

Departments of Pediatrics,¹ Microbiology and Immunology,² Anesthesiology,⁴ and Medicine,⁵ Vanderbilt University School of Medicine, Nashville, Tennessee, and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina³

Received 17 November 2000/Returned for modification 13 January 2001/Accepted 27 January 2001

We compared Roche MONITOR and Organon Teknika NucliSens assays for human immunodeficiency virus type 1 (HIV-1) RNA in cerebrospinal fluid (CSF). Results of 282 assays were highly correlated (r = 0.826), with MONITOR values being 0.29 ± 0.4 log₁₀ copies/ml (mean ± standard deviation) values. Both assays can reliably quantify HIV-1 RNA in CSF.

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^* Corresponding author. Mailing address: Vanderbilt University Medical Center, Pediatric Infectious Diseases, D-7235 MCN, Nashville, TN 37232-2581. Phone:(615) 322-2250. Fax: (615) 343-9723. E-mail: paul.spearman{at}mcmail.vanderbilt.edu.

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Journal of Clinical Microbiology, April 2001, p. 1612-1614, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.1612-1614.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

• Haas, D. W., Johnson, B. W., Spearman, P., Raffanti, S., Nicotera, J., Schmidt, D., Hulgan, T., Shepard, R., Fiscus, S. A. (2003). Two phases of HIV RNA decay in CSF during initial days of multidrug therapy. Neurology 61: 1391-1396 [Abstract] [Full Text]