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Journal of Clinical Microbiology, April 2001, p. 1652-1653, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.000-000.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Isolation of Amantadine-Resistant Influenza A Viruses (H3N2) from Patients following Administration of Amantadine in Japan

Jun Iwahashi,1 Katsuro Tsuji,1,2,3 Tetsuya Ishibashi,4 Junboku Kajiwara,4 Yoshihiro Imamura,1 Ryoichi Mori,4 Koyu Hara,1 Takahito Kashiwagi,1 Yasushi Ohtsu,1 Nobuyuki Hamada,1 Hisao Maeda,2 Michiko Toyoda,1 and Tetsuya Toyoda1,*

Departments of Virology1 and Neuro-Psychiatry,2 Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Ohmuta Municipal General Hospital, Ohmuta, Fukuoka 836-8567,3 and Fukuoka Institute of Health and Environmental Sciences, Dazaifu, Fukuoka 818-0135,4 Japan

Received 14 August 2000/Returned for modification 14 December 2000/Accepted 22 January 2001

In Japan, the use of amantadine for treatment of influenza A virus infection was not accepted until November 1998, although it was widely used for treatment of Parkinsonism. Since then, we have monitored the emergence of amantadine-resistant viruses and isolated two viruses from patients on long-term treatment with amantadine.

* Corresponding author. Mailing address: Department of Virology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan. Phone: 81-942-31-7549. Fax: 81-942-32-0903. E-mail: ttoyoda{at}med.kurume-u.ac.jp.

Journal of Clinical Microbiology, April 2001, p. 1652-1653, Vol. 39, No. 4
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.4.000-000.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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