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Journal of Clinical Microbiology, May 2001, p. 1928-1931, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1928-1931.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nationwide German Multicenter Study on the Prevalence of Antibiotic Resistance in Streptococcal Blood Isolates from Neutropenic Patients and Comparative In Vitro Activities of Quinupristin-Dalfopristin and Eight Other Antimicrobials

Ralf René Reinert,1,* Christof von Eiff,2 Michael Kresken,3,dagger Johannes Brauers,3,dagger Dieter Hafner,4 Adnan Al-Lahham,1 Holger Schorn,1 Rudolf Lütticken,1 Georg Peters,2 and The Multicenter Study On Antibiotic Resistance In Staphylococci and Other Gram- Positive Cocci (Mars) Study GroupDagger

Institute of Medical Microbiology, National Reference Centre for Streptococci, University Hospital, D-52057 Aachen,1 Institute of Medical Microbiology, Westfälische-Wilhelms-Universität, D-48149 Münster,2 Rhône Poulenc Rorer Arzneimittel GmbH, D-50829 Cologne,3 and Institute for Pharmacology, Heinrich-Heine-Universität, D-40225 Düsseldorf,4 Germany

Received 13 October 2000/Returned for modification 4 January 2001/Accepted 6 March 2001

In a prospective multicenter study (1996 to 1999), 156 episodes of bacteremic streptococcal infections of neutropenic patients were evaluated. Streptococcus oralis (26.3%), S. pneumoniae (26.3%), S. agalactiae (11.5%), S. mitis (9%), and S. pyogenes (5.8%) were the predominant species. Four strains (2.6%) were found to be intermediately resistant to penicillin. One strain (0.6%) was found to be highly resistant to penicillin (MIC, 8 mg/liter). Reduced susceptibility to penicillin was detected among S. oralis (14.6%), S. mitis (7.1%), and S. pneumoniae (4.9%) isolates but was not recorded among S. agalactiae and S. pyogenes. Resistance rates and intermediate resistance rates for other antimicrobials were as follows (all species): amoxicillin, 1.3 and 3.2%; erythromycin, 16 and 2.6%; clindamycin, 5.8 and 0%; ciprofloxacin, 1.9 and 7.7%. Quinupristin-dalfopristin showed good in vitro activity against most streptococcal isolates (MIC at which 50% of the isolates were inhibited [MIC50], 0.5 mg/liter; MIC90, 1 mg/liter, MIC range, 0.25 to 4 mg/liter).

* Corresponding author. Mailing address: Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstr. 30, D-52057 Aachen, Germany. Phone: 49 241 8089787. Fax: 49 241 8888483. E-mail: Reinert{at}rwth-aachen.de.

dagger Present address: Antiinfectives Intelligence GmbH, D-53121 Bonn, Germany.

Dagger Members of the Multicenter Study on Antibiotic Resistance in Staphylococci and Other Gram-Positive Cocci Study Group (all in Germany) are as follows: U. Hadding and F. J. Schmitz, Institute for Medical Microbiology and Virology, Heinrich-Heine-Universität Düsseldorf; D. Mack, Institute for Medical Microbiology and Immunology, University Hospital Eppendorf, Hamburg; U. Göbel and E. Halle, Institute for Medical Microbiology and Hygiene, Universitätsklinikum Charité, Humboldt-Universität, Berlin; J. Bader and B. Grabein, Max-von-Pettenkofer Institute for Medical Microbiology and Hygiene, Klinikum Grosshadern, Munich; W. Pfister and E. Straube, Institute for Medical Microbiology, Friedrich-Schiller-Universität, Jena; A.-F. Saleh, Städtisches Klinikum Merheim, Cologne; W. Bredt and A. Serr, Institute for Medical Microbiology and Hygiene, Albert-Ludwigs-Universität, Freiburg; B. Ganster and H. Geiss, Institute for Hygiene, Ruprecht-Karls-Universität, Heidelberg; S. Korn and P. M. Shah, Department of Infectious Diseases, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main; F. D. Daschner, U. Frank, and D. Mlangeni, Institute for Environmental Medicine and Hospital Hygiene, Albert-Ludwigs-Universität, Freiburg; E. Pleß and A. C. Rodloff, Institute for Medical Microbiology and Epidemiology of Infectious Diseases, Universität Leipzig; V. Brade and V. Schäfer, Institute for Hygiene, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main; H. Seifert, Institute for Hygiene, University of Cologne; H. Hahn and J. Wagner, Institute for Medical Microbiology, Universitätsklinikum Benjamin Franklin, Freie Universität, Berlin; K. Kamereck and T. Max, Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität, Munich; O. Zimmermann and E. Eiffert, Institute for Hygiene, Georg-August-Universität, Göttingen; G. Wichmann and E. Jacobs, Institute for Medical Microbiology and Hygiene, Technische Universität, Dresden; N. Lehn, Institute for Medical Microbiology and Hygiene, Friedrich-Alexander-Universität, Regensburg; D. Bitter-Suermann and S. Weber, Institute for Medical Microbiology, Medizinische Hochschule, Hannover.

Journal of Clinical Microbiology, May 2001, p. 1928-1931, Vol. 39, No. 5
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.5.1928-1931.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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