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Journal of Clinical Microbiology, July 2001, p. 2729-2731, Vol. 39, No. 7
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.7.2729-2731.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparative Evaluation of Penicillin, Ampicillin, and Imipenem MICs and Susceptibility Breakpoints for Vancomycin-Susceptible and Vancomycin-Resistant Enterococcus faecalis and Enterococcus faecium

Melvin P. Weinstein*

Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901-0019

Received 19 January 2001/Returned for modification 28 March 2001/Accepted 3 May 2001

Although imipenem has in vitro activity against Enterococcus faecalis and Food and Drug Administration-approved indications for treatment of infections caused by this microorganism, there are no NCCLS guidelines for susceptibility testing of imipenem versus enterococci. Therefore, the in vitro activities of penicillin, ampicillin, imipenem, and vancomycin against 201 blood isolates of E. faecalis and 24 blood isolates of Enterococcus faecium were compared. The susceptibility of isolates to penicillin or ampicillin accurately predicted the in vitro activity of imipenem. Since the susceptibility of enterococci to imipenem can be predicted by the results obtained by testing of penicillin or ampicillin, testing of imipenem by clinical laboratories probably is not necessary.

* Mailing address: Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, 1 Robert Wood Johnson Pl., New Brunswick, NJ 08901-0019. Phone: (732) 235-7713. Fax: (732) 235-7951. E-mail: weinstei{at}umdnj.edu.

Journal of Clinical Microbiology, July 2001, p. 2729-2731, Vol. 39, No. 7
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.7.2729-2731.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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