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Journal of Clinical Microbiology, September 2001, p. 3346-3349, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3346-3349.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Sequence Typing Confirms that Campylobacter jejuni Strains Associated with Guillain-Barré and Miller-Fisher Syndromes Are of Diverse Genetic Lineage, Serotype, and Flagella Type

K. E. Dingle,1 N. Van Den Braak,2 F. M. Colles,1 Lawrence J. Price,3 David L. Woodward,3 Frank G. Rodgers,3 H. P. Endtz,2 A. Van Belkum,2 and M. C. J. Maiden1,*

Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, United Kingdom1; Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands2; and National Laboratory for Enteric Pathogens, National Microbiology Laboratory, Winnipeg, MB R3E 3R2, Canada3

Received 22 May 2001/Returned for modification 26 June 2001/Accepted 28 June 2001

Guillain-Barré syndrome (GBS) and Miller-Fisher syndrome (MFS) are correlated with prior infection by Campylobacter jejuni in up to 40% of cases. Nucleotide sequence-based typing of 25 C. jejuni isolates associated with neuropathy permitted robust comparisons with equivalent data from approximately 800 C. jejuni isolates not associated with neuropathy. A total of 13 genetic lineages and 20 flaA short variable region nucleotide sequences were present among the 25 isolates. A minority of isolates (4 of 25) had the flaA short variable region nucleotide sequences that were previously proposed as a marker for GBS-associated isolates. These 4 isolates probably represented the Penner serotype 19 lineage, which has been proposed to have an association with GBS.

* Corresponding author. Present address: The Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Rd., Oxford, OX1 3FY, United Kingdom Phone: (44) (1865) 271284. Fax: (44) (1865) 271284. E-mail: martin.maiden{at}zoo.ox.ac.uk.

Journal of Clinical Microbiology, September 2001, p. 3346-3349, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3346-3349.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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