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Journal of Clinical Microbiology, September 2001, p. 3353-3355, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3353-3355.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Existence of Hepatitis C Virus in Culex quinquefasciatus after Ingestion of Infected Blood: Experimental Approach to Evaluating Transmission by Mosquitoes

Ting-Tsung Chang,1,* Tsuey-Yu Chang,2 Cheng-Chen Chen,3 Kung-Chia Young,4 Jun-Neng Roan,5 Yen-Chien Lee,5 Pin-Nan Cheng,5 and Hua-Lin Wu6

Institute of Clinical Medicine,1 Department of Parasitology,2 Department of Medical Technology,4 Department of Medicine,5 and Department of Biochemistry,6 College of Medicine, National Cheng Kung University, Tainan, and Department of Parasitology, National Yang Ming University, Taipei,3 Taiwan, Republic of China

Received 2 March 2001/Returned for modification 4 May 2001/Accepted 28 June 2001

We used PCR to detect hepatitis C virus (HCV) RNA among supernatants of ground Culex quinquefasciatus mosquitoes that (i) had been fed HCV-positive blood, (ii) had been intrathoracically inoculated with HCV-positive blood, or (iii) were from homes of hepatitis C patients. HCV RNA was detectable under all three conditions, but it did not replicate in mosquitoes and was not detectably transmitted during feeding.

* Corresponding author. Mailing address: Department of Clinical Medicine, National Cheng Kung University Hospital, 138 Shing-Li Rd., Tainan 704, Taiwan, Republic of China. Phone: (886) 6-235-3535, ext. 3643. Fax: (886) 6-209-5233. E-mail: ttchang{at}mail.ncku.edu.tw.

Journal of Clinical Microbiology, September 2001, p. 3353-3355, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3353-3355.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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