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Journal of Clinical Microbiology, September 2001, p. 3379-3381, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3379-3381.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Heteroresistance to Vancomycin in Enterococcus faecium

M. Rabiul Alam,1,2 Susan Donabedian,2 William Brown,3,4 James Gordon,1,4 Joseph W. Chow,1,4,5 Marcus J. Zervos,1,2,4,* and Ellie Hershberger2

Division of Infectious Disease, Department of Medicine,1 and DMC University Laboratories,3 William Beaumont Hospital,2 Royal Oak, and Veterans Administration Medical Center,5 and Department of Medicine, Wayne State University,4 Detroit, Michigan

Received 9 April 2001/Returned for modification 26 May 2001/Accepted 15 June 2001

This study presents the first report of vancomycin heteroresistance in an Enterococcus faecium isolate from a patient. The original isolate was susceptible in vitro to vancomycin. E-tests showed growth of subcolonies in a zone of inhibition with a vancomycin MIC of >256 µg/ml. Both the susceptible and resistant colonies were from the same strain as determined by PFGE, and both contained the vanA gene as determined by PCR.

* Corresponding author. Mailing address: William Beaumont Hospital, 3601 West 13 Mile Rd., Royal Oak, MI 48073. Phone: (248) 551-0419. Fax: (248) 551-5069. E-mail: Mzervos{at}Beaumont.edu.

Journal of Clinical Microbiology, September 2001, p. 3379-3381, Vol. 39, No. 9
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.9.3379-3381.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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