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Journal of Clinical Microbiology, January 2002, p. 298-300, Vol. 40, No. 1
0095-1137/02/$04.00+0 DOI: 10.1128/JCM.40.1.298-300.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.
Association of cagA and vacA Genotypes of Helicobacter pylori with Gastric Diseases in Estonia
Helena Andreson,1 Krista Lõivukene,1 Toomas Sillakivi,2 Heidi-Ingrid Maaroos,3 Mart Ustav,4 Ants Peetsalu,2 and Marika Mikelsaar1*
Department of Microbiology,1
Department of Surgery,2
Department of Polyclinic and Family Medicine,3
Institute of Molecular and Cell Biology, University of Tartu, Tartu 50411, Estonia4
Received 24 July 2001/
Returned for modification 3 September 2001/
Accepted 21 October 2001
Gastric biopsy specimens from 156 adult patients from southern Estonia suffering from chronic gastritis, peptic ulcer disease, and perforated peptic ulcer were analyzed by PCR. The cagA gene was evenly distributed throughout 87% of the specimens from the patients with the different gastric diseases. The presence of the cagA gene correlated with that of vacA signal sequence type s1a (99%). However, no clear differences were found in the distribution of cagA and vacA genotypes among patients in Estonia with severe perforated peptic ulcer, uncomplicated peptic ulcer, or chronic gastritis.
* Corresponding author. Mailing address: Department of Microbiology, University of Tartu, Ravila 19, Tartu 50411, Estonia. Phone: 372 7 374 171. Fax: 372 7 374 172. E-mail:
marikam{at}ut.ee.
Journal of Clinical Microbiology, January 2002, p. 298-300, Vol. 40, No. 1
0095-1137/02/$04.00+0 DOI: 10.1128/JCM.40.1.298-300.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.
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