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Journal of Clinical Microbiology, October 2002, p. 3822-3825, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3822-3825.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Assessment of a Combined Testing Strategy for Detection of Antibodies to Human Herpesvirus 8 (HHV-8) in Persons with Kaposi's Sarcoma, Persons with Asymptomatic HHV-8 Infection, and Persons at Low Risk for HHV-8 Infection

Corey Casper,1* Elizabeth Krantz,2 Heather Taylor,2 Julie Dalessio,2 David Carrell,2 Anna Wald,1,2,3 Lawrence Corey,1,2,4 and Rhoda Ashley2

Departments of Medicine,1 Laboratory Medicine,2 Epidemiology, University of Washington School of Medicine,3 Program in Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, Washington4

Received 8 January 2002/ Returned for modification 29 March 2002/ Accepted 16 June 2002

The performance of a human herpesvirus 8 (HHV-8) enzyme immunoassay (EIA) and selective subsequent use of an HHV-8 immunofluorescence assay (IFA) was tested in persons unlikely to be infected with HHV-8 and those who had HHV-8 detected in their saliva. The IFA was performed on samples within a range of EIA optical densities (0.15 to 0.35) where there was considerable overlap between HHV-8-infected and uninfected individuals. The sensitivity of the testing strategy was 88%, with a specificity of 97%.

* Corresponding author. Mailing address: Virology Research Clinic, University of Washington, Box 359928, Seattle, WA 98195. Phone: (206) 720-4340. Fax: (206) 720-4371. E-mail: ccasper{at}u.washington.edu.

Journal of Clinical Microbiology, October 2002, p. 3822-3825, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3822-3825.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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