This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Warren, R. M.
Right arrow Articles by Victor, T. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Warren, R. M.
Right arrow Articles by Victor, T. C.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, October 2002, p. 3851-3853, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3851-3853.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Use of Spoligotyping for Accurate Classification of Recurrent Tuberculosis

R. M. Warren,1 E. M. Streicher,1 S. Charalambous,2 G. Churchyard,2 G. D. van der Spuy,1 A. D. Grant,3 P. D. van Helden,1* and T. C. Victor1

MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg 7505,1 Aurum Health Research, Welkom, South Africa,2 Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom3

Received 22 May 2002/ Returned for modification 18 June 2002/ Accepted 8 July 2002

The spoligotyping method has become an important tool for the tracking of Mycobacterium tuberculosis strains in different epidemiological settings. In this study, we demonstrate the ability of the spoligotyping technique to accurately determine the pathogenetic mechanism of recurrent disease. This methodology has advantages over conventional restriction fragment length polymorphism methods which may be useful in large- scale intervention studies.

* Corresponding author. Mailing address: MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, P.O. Box 19063, Tygerberg 7505, South Africa. Phone: 27-21-9389401. Fax: 27-21-9317810 or 27-21-9389476. E-mail: pvh{at}sun.ac.za.

Journal of Clinical Microbiology, October 2002, p. 3851-3853, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3851-3853.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Evans, J. T., Hawkey, P. M., Smith, E. G., Boese, K. A., Warren, R. E., Hong, G. (2004). Automated High-Throughput Mycobacterial Interspersed Repetitive Unit Typing of Mycobacterium tuberculosis Strains by a Combination of PCR and Nondenaturing High-Performance Liquid Chromatography. J. Clin. Microbiol. 42: 4175-4180 [Abstract] [Full Text]  
  • Hawkey, P. M., Smith, E. G., Evans, J. T., Monk, P., Bryan, G., Mohamed, H. H., Bardhan, M., Pugh, R. N. (2003). Mycobacterial Interspersed Repetitive Unit Typing of Mycobacterium tuberculosis Compared to IS6110-Based Restriction Fragment Length Polymorphism Analysis for Investigation of Apparently Clustered Cases of Tuberculosis. J. Clin. Microbiol. 41: 3514-3520 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»