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Journal of Clinical Microbiology, October 2002, p. 3860-3862, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3860-3862.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

High Prevalence of cagA- and babA2-Positive Helicobacter pylori Clinical Isolates in Taiwan

Chih-Ho Lai,1 Chun-Hsien Kuo,1 Ya-Chi Chen,1 Fang-Yu Chao,1 Sek-Kwong Poon,2 Chi-Sen Chang,2 and Wen-Ching Wang1*

Department of Life Sciences, National Tsing Hua University, Hsinchu,1 Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan2

Received 18 April 2002/ Returned for modification 3 June 2002/ Accepted 14 July 2002

Two virulence markers, cagA and babA2, were characterized by PCR in 101 Helicobacter pylori isolates from a population in Taiwan. cagA was detected in 99% of the isolates, while babA2 was present in all of the isolates. Base deletions and substitutions at the forward babA2 primer annealing sites were found. Given their high prevalence, cagA and babA2 cannot be useful markers for predicting the high-risk patients of H. pylori infection in Taiwan.

* Corresponding author. Mailing address: Department of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan 300. Phone: 886-3-5742766. Fax: 886-3-5742766. E-mail: wcwang{at}life.nthu.edu.tw.

Journal of Clinical Microbiology, October 2002, p. 3860-3862, Vol. 40, No. 10
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.10.3860-3862.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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