This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wever, P. C.
Right arrow Articles by van Gool, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wever, P. C.
Right arrow Articles by van Gool, T.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, December 2002, p. 4729-4731, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4729-4731.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Detection of Imported Malaria with the Cell-Dyn 4000 Hematology Analyzer

Peter C. Wever,1* Yvonne M. C. Henskens,2 Piet A. Kager,3 Jacob Dankert,1 and Tom van Gool1

Section of Parasitology, Department of Medical Microbiology,1 Department of Clinical Chemistry,2 Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands3

Received 5 March 2002/ Returned for modification 29 May 2002/ Accepted 23 July 2002

The sensitivity and specificity of the Cell-Dyn 4000 hematology analyzer in the diagnosis of imported malaria were studied with samples from patients in an academic hospital setting. The performance of the Cell-Dyn 4000 hematology analyzer was compared with that of conventional diagnostic methods for malaria. The Cell-Dyn 4000 hematology analyzer detected hemozoin-containing depolarizing monocytes in 29 of 58 patients with malaria and 2 of 55 patients without malaria. The presence or absence of depolarizing monocytes in patients with malaria was related to duration of symptoms before presentation for malaria analysis. A second parameter, pseudoreticulocytosis due to nuclear material of intraerythrocytic malaria parasites, was detected by the Cell-Dyn 4000 hematology analyzer almost exclusively in Plasmodium falciparum malaria patients with parasitemia levels of >=0.5%. Attention to these abnormalities in medical centers without tropical disease expertise may decrease a delay in the diagnosis of malaria.

* Corresponding author. Mailing address: Department of Medical Microbiology L1-104, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. Phone: 31 (0)20 566 9111. Fax: 31 (0)20 697 9271. E-mail: p.c.wever{at}amc.uva.nl.

Journal of Clinical Microbiology, December 2002, p. 4729-4731, Vol. 40, No. 12
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.12.4729-4731.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»