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Journal of Clinical Microbiology, February 2002, p. 657-659, Vol. 40, No. 2
0095-1137/01/$04.00+0     DOI: 10.1128/JCM.40.2.657-659.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Discrimination of Single-Copy IS6110 DNA Fingerprints of Mycobacterium tuberculosis Isolates by High-Resolution Minisatellite-Based Typing

Ann S. G. Lee,1,2* Lynn L. H. Tang,3 Irene H. K. Lim,3 Richard Bellamy,3 and Sin-Yew Wong3

Department of Clinical Research, Singapore General Hospital, Singapore 169608,1 Division of Medical Sciences, National Cancer Centre, Singapore 169610,2 Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore 3084333

Received 17 May 2001/ Returned for modification 28 October 2001/ Accepted 21 November 2001

Seven isoniazid-resistant isolates with mutations in the NADH dehydrogenase (ndh) gene were molecularly typed by IS6110-based restriction fragment length polymorphism analysis. All seven isolates with the R268H mutation had identical 1.4-kb IS6110 fingerprints. High-resolution minisatellite-based typing discriminated five of these isolates; two isolates were identical.

* Corresponding author. Mailing address: Division of Medical Sciences, National Cancer Centre, Republic of Singapore 169610. Phone: 65-4368313. Fax: 65-372 0161. E-mail: dmslsg{at}nccs.com.sg.

Journal of Clinical Microbiology, February 2002, p. 657-659, Vol. 40, No. 2
0095-1137/01/$04.00+0     DOI: 10.1128/JCM.40.2.657-659.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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