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Journal of Clinical Microbiology, March 2002, p. 1063-1066, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1063-1066.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Antimicrobial Surveillance of Haemophilus influenzae in the United States during 2000-2001 Leads to Detection of Clonal Dissemination of a ß-Lactamase-Negative and Ampicillin-Resistant Strain

James A. Karlowsky,1* Ian A. Critchley,1 Renée S. Blosser-Middleton,1 Elena A. Karginova,1 Mark E. Jones,2 Clyde Thornsberry,1 and Daniel F. Sahm1

Focus Technologies, Inc., Herndon, Virginia 20171,1 1217 KP Hilversum, The Netherlands2

Received 24 October 2001/ Returned for modification 2 December 2001/ Accepted 20 December 2001

A 2000-2001 U.S. Haemophilus influenzae surveillance study (n = 1,434) detected nine (0.6%) ß-lactamase-negative and ampicillin-resistant (BLNAR) isolates collected from two different hospitals. The MICs of ampicillin for all nine isolates were 4 µg/ml, with results being reproducible; and all nine isolates were susceptible to amoxicillin-clavulanate, cefuroxime, cefprozil, macrolides, and fluoroquinolones. Pulsed-field gel electrophoresis of genomic DNA following SmaI digestion demonstrated identical patterns for each of the nine isolates, suggesting intra- and interhospital dissemination of a BLNAR clone.

* Corresponding author. Mailing address: Focus Technologies, Inc., 13665 Dulles Technology Dr., Suite 200, Herndon, VA 20171-4603. Phone: (703) 480-2575. Fax: (703) 480-2654. E-mail: jkarlowsky{at}focusanswers.com.

Journal of Clinical Microbiology, March 2002, p. 1063-1066, Vol. 40, No. 3
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.3.1063-1066.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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