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Journal of Clinical Microbiology, April 2002, p. 1546-1548, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1546-1548.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Production of BRO ß-Lactamases and Resistance to Complement in European Moraxella catarrhalis Isolates

Franz-Josef Schmitz,1,2* Andreas Beeck,1 Mirella Perdikouli,1 Mechthild Boos,1 Susanne Mayer,1 Sybille Scheuring,1 Karl Köhrer,1 Jan Verhoef,2 and Ad C. Fluit2

Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany,1 Eijkman-Winkler Institute for Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands2

Received 21 August 2001/ Returned for modification 4 October 2001/ Accepted 19 January 2002

Of the 419 Moraxella catarrhalis isolates collected during the 1997-1999 European SENTRY surveillance study, 385 (92%) were ß-lactamase positive. Twenty-two (5.7%) produced BRO-2 ß-lactamase. Twenty-one new mutations were found in the putative promoter region of the bro genes. Nineteen percent of all isolates tested were complement sensitive. Resistance to ß-lactams is not linked to the phylogenetic lineages associated with susceptibility to complement.

* Corresponding author. Mailing address: Institute for Medical Microbiology and Virology, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, Geb. 22.21, D-40225 Düsseldorf, Germany. Phone and fax: 0049-2132-72040. E-mail: schmitfj{at}uni-duesseldorf.de.

Journal of Clinical Microbiology, April 2002, p. 1546-1548, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1546-1548.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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