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Journal of Clinical Microbiology, April 2002, p. 1549-1552, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1549-1552.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Emerging Extended-Spectrum ß-Lactamases in Proteus mirabilis

Laura Pagani,1* Roberta Migliavacca,1 Lucia Pallecchi,2 Cecilia Matti,3 Ernesto Giacobone,3 Gianfranco Amicosante,4 Egidio Romero,1 and Gian Maria Rossolini2*

Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Università di Pavia,1 Servizio di Analisi Microbiologiche I.R.C.C.S. S. Matteo, I-27100, Pavia,3 Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100, Siena,2 Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100, L'Aquila, Italy4

Received 30 August 2001/ Returned for modification / Accepted 20 January 2002

ß-Lactamase production was detected in 147 (52%) of 282 consecutive nonduplicate Proteus mirabilis isolates obtained over a 1-year period from the S. Matteo Hospital of Pavia (northern Italy). Seventy isolates (48% of the ß-lactamase producers) were found to produce extended-spectrum ß-lactamases (ESBLs), identified as PER-1 (first report in this species) and TEM-52 in 52 and 18 isolates, respectively. Analysis of clonal diversity of the ESBL producers suggested different spreading patterns for the two ESBL determinants.

* Corresponding author. Mailing address for Laura Pagani: Dipartimento di Scienze Morfologiche, Eidologiche e Cliniche, Sezione di Microbiologia, Università di Pavia, Via Brambilla, 74, I-27100, Pavia, Italy. Phone: 39 0382 526335. Fax: 39 0382 525886. E-mail: lpagani{at}unipv.it. Mailing address for Gian Maria Rossolini: Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Policlinico "Le Scotte," I-53100, Siena, Italy. Phone: 39 0577 233455. Fax: 39 0577 233325. E-mail: rossolini{at}unisi.it.

Journal of Clinical Microbiology, April 2002, p. 1549-1552, Vol. 40, No. 4
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.4.1549-1552.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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