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Journal of Clinical Microbiology, June 2002, p. 2220-2223, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2220-2223.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Evaluation of the Subtype Specificity of Monoclonal Antibodies Raised against H1 and H3 Subtypes of Human Influenza A Virus Hemagglutinins

Eva Varecková,1* Nancy Cox,2 and Alexander Klimov2

Institute of Virology, Slovak Academy of Sciences, 842 45 Bratislava, Slovak Republic,1 Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303332

Received 11 October 2001/ Returned for modification 7 January 2002/ Accepted 30 March 2002

Three previously described monoclonal antibodies (MAbs) specific for influenza A(H1) hemagglutinins (HA) revealed high sensitivity (98.2 to 99.1%) and specificity (100%) when tested against 245 strains of different subtypes. One of them was included in the World Health Organization's influenza reagent kit for 2001 to 2002. In contrast, two MAbs raised against human influenza A(H3) HA revealed cross-reactivity with viruses of other subtypes.

* Corresponding author. Mailing address: Institute of Virology, Slovak Academy of Sciences, Dúbravská cesta 9, 842 45 Bratislava, Slovak Republic. Phone: 421-2-59302443. Fax: 421-2-54774284. E-mail: viruevar{at}nic.savba.sk.

Journal of Clinical Microbiology, June 2002, p. 2220-2223, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2220-2223.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Gocnik, M., Fislova, T., Sladkova, T., Mucha, V., Kostolansky, F., Vareckova, E. (2007). Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion-inhibition activity contribute to the protection of mice against lethal infection. J. Gen. Virol. 88: 951-955 [Abstract] [Full Text]  


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