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Journal of Clinical Microbiology, June 2002, p. 2305-2307, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2305-2307.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Failure of Commercial Ligase Chain Reaction To Detect Mycobacterium tuberculosis DNA in Sputum Samples from a Patient with Smear-Positive Pulmonary Tuberculosis Due to a Deletion of the Target Region

Christopher M. Gilpin,1* David J. Dawson,1 Gabrielle O'Kane,1 John G. Armstrong,2 and Christopher Coulter1

Mycobacterium Reference Laboratory, Division of Microbiology, The Prince Charles Hospital, Chermside 4032,1 Department of Respiratory Medicine, Princess Alexandra Hospital, Wooloongabba 4102, Australia2

Received 6 December 2001/ Returned for modification 21 January 2002/ Accepted 24 March 2002

We report on a strain of Mycobacterium tuberculosis with a deletion in the protein antigen B gene overlapping the probe binding sites for the Abbott Diagnostics LCx M. tuberculosis (LCx-MTB) probe assay. A false-negative result with the LCx-MTB assay delayed a laboratory diagnosis of tuberculosis.

* Corresponding author. Mailing address: Mycobacterium Reference Laboratory, Division of Microbiology, The Prince Charles Hospital, Rode Rd., Chermside 4032, Australia. Phone: 61 7 3212 5149. Fax: 61 7 3350 8553. E-mail: Chris_Gilpin{at}health.qld.gov.au.

Journal of Clinical Microbiology, June 2002, p. 2305-2307, Vol. 40, No. 6
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.6.2305-2307.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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