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Journal of Clinical Microbiology, July 2002, p. 2648-2650, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2648-2650.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Nationwide Survey of In Vitro Activities of Itraconazole and Voriconazole against Clinical Aspergillus fumigatus Isolates Cultured between 1945 and 1998

Paul E. Verweij,1* Debbie T. A. Te Dorsthorst,1,2 Anthonius J. M. M. Rijs,1 Hilly G. De Vries-Hospers,3 Jacques F. G. M. Meis,2 and the Dutch Interuniversity Working Party for Invasive Mycoses

Department of Medical Microbiology, University Medical Center Nijmegen,1 Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen,2 Department of Medical Microbiology, University Hospital Groningen, Groningen, The Netherlands3

Received 14 January 2002/ Returned for modification 2 March 2002/ Accepted 10 April 2002

The isolates in a collection of 170 Aspergillus fumigatus isolates recovered from 114 patients and 21 different medical centers in The Netherlands over a period of 53 years were tested for the presence of resistance to itraconazole and voriconazole according to the guidelines of NCCLS document M38-P and by the E-test. Three isolates were highly resistant to itraconazole, and voriconazole MICs were low for all isolates.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax: 31-24-3540216. E-mail: p.verweij{at}mmb.azn.nl.

Journal of Clinical Microbiology, July 2002, p. 2648-2650, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2648-2650.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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