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Journal of Clinical Microbiology, July 2002, p. 2677-2680, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2677-2680.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Spoligotyping of Mycobacterium tuberculosis Isolates from Multiple-Drug-Resistant Tuberculosis Patients from Bombay, India

Nerges F. Mistry,1* Anand M. Iyer,1 Desirée T. B. D'souza,1 G. Michael Taylor,2 Douglas B. Young,2 and Noshir H. Antia1

The Foundation for Medical Research, Bombay 400018, India,1 Department of Infectious Disease and Microbiology, Centre for Molecular Microbiology and Infection, Faculty of Medicine, Imperial College School of Science, Technology, and Medicine, London SW7 2AZ, United Kingdom2

Received 10 December 2001/ Returned for modification 12 March 2002/ Accepted 7 April 2002

Spoligotyping was undertaken in 65 multiple-drug-resistant Mycobacterium tuberculosis isolates from Bombay, India. The spoligotype patterns showed seven closely related clusters, a cluster with 2 Beijing-like isolates, and unique spoligotypes (43%). Of the clusters, one with 29% of all the isolates suggested transmission of a dominant resistant clone.

* Corresponding author. Mailing address: The Foundation for Medical Research, 84-A, R.G. Thadani Marg, Worli, Bombay 400018, India. Phone: 91 22 4934989. Fax: 91 22 4932876. E-mail: frchbom{at}bom2.vsnl.net.in.

Journal of Clinical Microbiology, July 2002, p. 2677-2680, Vol. 40, No. 7
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.7.2677-2680.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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