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Journal of Clinical Microbiology, August 2002, p. 2994-2998, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2994-2998.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Phenotypic and Genetic Diversity of Invasive Pneumococcal Isolates Recovered from French Children

Catherine Doit,1 Chawki Loukil,1 Pierre Geslin,2 and Edouard Bingen1*

Service de Microbiologie, Hôpital Robert Debré, Paris,1 Centre National de Référence des Pneumocoques, Centre Hospitalier Intercommunal, Créteil, France2

Received 15 February 2002/ Returned for modification 31 March 2002/ Accepted 4 May 2002

We investigated the phenotypic and genetic diversity (by ribotyping) of Streptococcus pneumoniae isolates recovered from French children, by blood culture from meningitis-free patients (n = 244) and by cerebrospinal fluid culture from patients with meningitis (n = 154). Isolates belonging to serotypes associated with carriage and penicillin-resistant isolates were significantly more frequent in children under 2 years of age than in older children. The seven-valent pneumococcal conjugate vaccine covered 68% of strains associated with bacteremia and 61% of strains associated with meningitis in children under 2 years. Although some serotypes were recovered more frequently from children with bacteremia than from those with meningitis, no difference in the genetic backgrounds of the two groups of strains was found.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital Robert Debré, 48 Bd Sérurier, 75019 Paris, France. Phone: 33 (1) 40 03 23 40. Fax: 33 (1) 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Journal of Clinical Microbiology, August 2002, p. 2994-2998, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.2994-2998.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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