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Journal of Clinical Microbiology, August 2002, p. 3038-3040, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.3038-3040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Presence of Integron-Associated Resistance in the Community Is Widespread and Contributes to Multidrug Resistance in the Hospital

M. A. Leverstein-van Hall,* A. Paauw, A. T. A. Box, H. E. M. Blok, J. Verhoef, and A. C. Fluit

Eijkman-Winkler Institute for Microbiology, Infectious Diseases & Inflammation, University Medical Center, Utrecht, The Netherlands

Received 11 March 2002/ Returned for modification 18 April 2002/ Accepted 12 May 2002

Integrons are strongly associated with the multidrug resistance seen in gram-negative bacilli in the hospital environment. No data, however, are available on their prevalence in the community. This study is the first to show that integrons are widespread in Enterobacteriaceae in the community and that integron-associated resistance genes in the community constitute a substantial reservoir for multidrug resistance in the hospital.

* Corresponding author. Mailing address: Eijkman-Winkler Institute for Microbiology, Infectious Diseases & Inflammation, University Medical Center Utrecht, Room G04.614, P.O. Box 85000, 3508 GA Utrecht, The Netherlands. Phone: 31 (0)30 2507 625. Fax: 31 (0)30 2541 770. E-mail: M.LeversteinvHall{at}lab.azu.nl.

Journal of Clinical Microbiology, August 2002, p. 3038-3040, Vol. 40, No. 8
0095-1137/02/$04.00+0     DOI: 10.1128/JCM.40.8.3038-3040.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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