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Journal of Clinical Microbiology, January 2003, p. 449-452, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.449-452.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Comparison of Washing and Swabbing Procedures for Collecting Genital Fluids To Assess Shedding of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Asymptomatic HIV-1-Infected Women

Laurent Andréoletti,1* Gérard Grésenguet,2 Nicolas Chomont,3 Mathieu Matta,4 Yann Quiniou,4 Ali Si-Mohamed,4 and Laurent Bélec3,4,5

Laboratoire de Virologie, Centre Hospitalier Universitaire, IFR 53/EA-3309, Faculté de Médecine de Reims, Reims,1 Unité 430, Hôpital Broussais, Institut National de la Santé et de la Recherche Médicale,3 Université Pierre et Marie Curie (Paris VI),5 Laboratoire de Virologie, Hôpital Européen Georges Pompidou, Paris, France,4 Centre National de Référence des Maladies Sexuellement Transmissibles et du SIDA, Bangui, Central African Republic2

Received 17 April 2002/ Returned for modification 11 September 2002/ Accepted 24 October 2002

Human immunodeficiency virus type 1 (HIV-1) RNA was detected by means of ultrasensitive reverse transcription-PCR assay of 19 cervicovaginal lavage, 21 cervical mucus, 18 vaginal wall, and 17 vaginal fornix paired samples from 25 asymptomatic HIV-1-infected women (76, 84, 72, and 68%, respectively; P > 0.5). Levels of HIV-1 RNA in cervicovaginal wash samples were highly correlated with those in paired endocervical mucus samples (r = 0.71; P = 0.0006), indicating that cervicovaginal washing and endocervical swabbing are equivalent collection procedures.

* Corresponding author. Mailing address: Laboratoire de Virologie, Service de Microbiologie, Hôpital Robert Debré, Avenue du Général Koenig, 51092 Reims Cedex, France. Phone: (33) 3 26 78 77 02. Fax: (33) 3 26 78 41 34. E-mail: landreoletti{at}chu-reims.fr.

Journal of Clinical Microbiology, January 2003, p. 449-452, Vol. 41, No. 1
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.1.449-452.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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