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Journal of Clinical Microbiology, October 2003, p. 4894-4897, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4894-4897.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Occurrence of Renal and Pulmonary Syndrome in a Region of Northeast Germany Where Tula Hantavirus Circulates

Boris Klempa,¹ Helga Meisel,¹ Silvana Räth,² Jan Bartel,³ Rainer Ulrich,¹ and Detlev H. Krüger^1*

Institute of Virology, Charité Medical School, Humboldt University, D-10098 Berlin,¹ Department of Internal Medicine, Spreewaldklinik, D-15907 Lübben,² Limbach Laboratory, D-69126 Heidelberg, Germany³

Received 23 December 2002/ Returned for modification 5 May 2003/ Accepted 12 July 2003

Hantavirus species Tula (TULV) is carried by European common voles (Microtus spp.). Its pathogenic potential for humans is unknown. In a rural region of northeast Germany, a 43-year-old man became ill with fever, renal syndrome, and pneumonia. Typing of late acute- and convalescent-phase sera by focus reduction neutralization assay revealed the presence of neutralizing antibodies against TULV. Moreover, we detected TULV genetic material in Microtus arvalis animals that were trapped at places only a few kilometers from the home village of the patient. Phylogenetic analysis of completely sequenced genomic S segments from three virus strains grouped them within a third genetic lineage of the TULV species. This is the first case of hemorrhagic fever with renal syndrome and pulmonary involvement which can be associated with TULV infection.

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* Corresponding author. Mailing address: Institute of Virology, Charité Medical School, Humboldt University, D-10098 Berlin, Germany. Phone: 49-30-450 525 092. Fax: 49-30-450 525 907. E-mail: detlev.kruger{at}charite.de.

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Journal of Clinical Microbiology, October 2003, p. 4894-4897, Vol. 41, No. 10
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.10.4894-4897.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

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