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Journal of Clinical Microbiology, November 2003, p. 5298-5301, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5298-5301.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Deep Infection by Trichophyton rubrum in an Immunocompromised Patient

Ran Nir-Paz,1,2 Hila Elinav,2 Gerald E. Pierard,3 David Walker,4 Alexander Maly,5 Mervyn Shapiro,1 Richard C. Barton,4 and Itzhack Polacheck1*

Departments of Clinical Microbiology and Infectious Diseases,1 Medicine,2 Pathology, Hadassah—Hebrew University Medical Center, Jerusalem, Israel,5 Department of Dermatopathology, University Medical Center Sart Tilman, Liège, Belgium,3 Division of Microbiology, University of Leeds and Mycology Reference Center, General Infirmary, Leeds LS2 9JT, United Kingdom4

Received 14 April 2003/ Returned for modification 26 May 2003/ Accepted 26 June 2003

Dermatophytes are common pathogens of skin but rarely cause invasive disease. We present a case of deep infection by Trichophyton rubrum in an immunocompromised patient. T. rubrum was identified by morphological characteristics and confirmed by PCR. Invasiveness was apparent by histopathology and immunohistochemistry. The patient was treated successfully with itraconazole.

* Corresponding author. Mailing address: Department of Clinical Microbiology and Infectious Diseases, Hadassah—Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel. Phone: 972-2-6776592. Fax: 972-2-6419545. E-mail: Itzhack.Polacheck{at}huji.ac.il.

Journal of Clinical Microbiology, November 2003, p. 5298-5301, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5298-5301.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • Maranhao, F. C. A., Paiao, F. G., Fachin, A. L., Martinez-Rossi, N. M. (2009). Membrane transporter proteins are involved in Trichophyton rubrum pathogenesis. J Med Microbiol 58: 163-168 [Abstract] [Full Text]  
  • Shehata, A. S., Mukherjee, P. K., Ghannoum, M. A. (2008). Comparison between the Standardized Clinical and Laboratory Standards Institute M38-A2 Method and a 2,3-Bis(2-Methoxy-4-Nitro-5-[(Sulphenylamino)Carbonyl]-2H-Tetrazolium Hydroxide- Based Method for Testing Antifungal Susceptibility of Dermatophytes. J. Clin. Microbiol. 46: 3668-3671 [Abstract] [Full Text]  
  • Kaufman, G., Berdicevsky, I., Woodfolk, J. A., Horwitz, B. A. (2005). Markers for Host-Induced Gene Expression in Trichophyton Dermatophytosis. Infect. Immun. 73: 6584-6590 [Abstract] [Full Text]  
  • Woodfolk, J. A. (2005). Allergy and Dermatophytes. Clin. Microbiol. Rev. 18: 30-43 [Abstract] [Full Text]  


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