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Journal of Clinical Microbiology, November 2003, p. 5340-5343, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5340-5343.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Outbreak of Saccharomyces cerevisiae Subtype boulardii Fungemia in Patients Neighboring Those Treated with a Probiotic Preparation of the Organism

III Clinica Medica, Dipartimento di Medicina Clinica, Università degli Studi di Roma "La Sapienza,",¹ Dipartimento di Malattie infettive, parassitarie ed immunomediate, Istituto Superiore di Sanità,² Reparto di Rianimazione e Terapia Intensiva, Ospedale "Sandro Pertini," Rome, Italy³

Received 4 February 2003/ Returned for modification 26 April 2003/ Accepted 7 August 2003

We report an outbreak of Saccharomyces cerevisiae subtype boulardii fungemia among three intensive care unit roommates of patients receiving lyophilized preparations of this fungus. The fungemia was probably due to central venous catheter contamination and resolved after fluconazole treatment. The need for stringent application of proper hygiene when using a probiotic preparation of this organism is emphasized.

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