This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baddley, J. W.
Right arrow Articles by Moser, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baddley, J. W.
Right arrow Articles by Moser, S. A.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, December 2003, p. 5525-5529, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5525-5529.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Epidemiology of Aspergillus terreus at a University Hospital

John W. Baddley,1* Peter G. Pappas,1 Anita C. Smith,2 and Stephen A. Moser2

Department of Medicine, Division of Infectious Diseases,1 Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama2

Received 14 May 2003/ Returned for modification 7 July 2003/ Accepted 20 September 2003

Invasive fungal infections due to Aspergillus species have become a major cause of morbidity and mortality among immunocompromised patients. Aspergillus terreus, a less common pathogen, appears to be an emerging cause of infection at our institution, the University of Alabama hospital in Birmingham. We therefore investigated the epidemiology of A. terreus over the past 6 years by using culture data; antifungal susceptibility testing with amphotericin B, voriconazole, and itraconazole; and molecular typing with random amplification of polymorphic DNA-PCR (RAPD-PCR). During the study period, the percentage of A. terreus isolates relative to those of other Aspergillus species significantly increased, and A. terreus isolates frequently were resistant to amphotericin B. Molecular typing with the RAPD technique was useful in discriminating between patient isolates, which showed much strain diversity. Further surveillance of A. terreus may better define epidemiology and determine whether this organism is becoming more frequent in relation to other Aspergillus species.

* Corresponding author. Mailing address: University of Alabama at Birmingham, Department of Medicine, Division of Infectious Diseases, 1900 University Blvd., 229 Tinsley Harrison Tower, Birmingham, AL 35294-0006. Phone: (205) 934-5191. Fax: (205) 934-5155. E-mail: jbaddley{at}uab.edu.

Journal of Clinical Microbiology, December 2003, p. 5525-5529, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5525-5529.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Balajee, S. A., Baddley, J. W., Peterson, S. W., Nickle, D., Varga, J., Boey, A., Lass-Florl, C., Frisvad, J. C., Samson, R. A., and the ISHAM Working Group on A. terreus, (2009). Aspergillus alabamensis, a New Clinically Relevant Species in the Section Terrei. Eukaryot Cell 8: 713-722 [Abstract] [Full Text]  
  • Pagano, L., Fianchi, L., Caira, M. (2008). Pulmonary aspergillosis in hematologic malignancies: lights and shadows. haematol 93: 1611-1616 [Full Text]  
  • Harris, J. B., Michelow, I. C., Westra, S. J., Kradin, R. L. (2008). Case 21-2008 -- An 11-Month-Old Boy with Fever and Pulmonary Infiltrates. NEJM 359: 178-187 [Full Text]  
  • Chowdhry, R., Marshall, W. L. (2008). Analytical Reviews: Antifungal Therapies in the Intensive Care Unit. J Intensive Care Med 23: 151-158 [Abstract]  
  • Lass-Florl, C., Grif, K., Kontoyiannis, D. P. (2007). Molecular Typing of Aspergillus terreus Isolates Collected in Houston, Texas, and Innsbruck, Austria: Evidence of Great Genetic Diversity. J. Clin. Microbiol. 45: 2686-2690 [Abstract] [Full Text]  
  • Pfaller, M. A., Diekema, D. J. (2007). Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem. Clin. Microbiol. Rev. 20: 133-163 [Abstract] [Full Text]  
  • Caston, J. J., Linares, M. J., Gallego, C., Rivero, A., Font, P., Solis, F., Casal, M., Torre-Cisneros, J. (2007). Risk Factors for Pulmonary Aspergillus terreus Infection in Patients With Positive Culture for Filamentous Fungi. Chest 131: 230-236 [Abstract] [Full Text]  
  • Balajee, S.A., Houbraken, J., Verweij, P.E., Hong, S-B., Yaghuchi, T., Varga, J., Samson, R.A. (2007). Aspergillus species identification in the clinical setting. SIM 59: 39-46 [Abstract] [Full Text]  
  • Enoch, D. A., Ludlam, H. A., Brown, N. M. (2006). Invasive fungal infections: a review of epidemiology and management options.. J Med Microbiol 55: 809-818 [Abstract] [Full Text]  
  • Pfaller, M. A., Diekema, D. J. (2004). Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyond Candida albicans and Aspergillus fumigatus. J. Clin. Microbiol. 42: 4419-4431 [Full Text]  
  • Steinbach, W. J., Perfect, J. R., Schell, W. A., Walsh, T. J., Benjamin, D. K. Jr. (2004). In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection. Antimicrob. Agents Chemother. 48: 3217-3225 [Full Text]  
  • de Aguirre, L., Hurst, S. F., Choi, J. S., Shin, J. H., Hinrikson, H. P., Morrison, C. J. (2004). Rapid Differentiation of Aspergillus Species from Other Medically Important Opportunistic Molds and Yeasts by PCR-Enzyme Immunoassay. J. Clin. Microbiol. 42: 3495-3504 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»