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Journal of Clinical Microbiology, February 2003, p. 838-840, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.838-840.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clinical Utility of Urinary Antigen Detection for Diagnosis of Community-Acquired, Travel-Associated, and Nosocomial Legionnaires' Disease

Jürgen H. Helbig,1* Søren A. Uldum,2 Sverker Bernander,3 Paul Christian Lück,1 Günther Wewalka,4 Bill Abraham,5 Valeria Gaia,6 and Timothy G. Harrison7

Institut Medizinische Mikrobiologie und Hygiene, Medizinische Fakultät TU Dresden, Dresden, Germany,1 Department of Respiratory Infections, Meningitis and STIs, Statens Serum Institut, Copenhagen, Denmark,2 Karolinska Hospital, Stockholm, Sweden,3 Bundesstaatliche Baktiologisch-serologische Untersuchungsanstalt, Vienna, Austria,4 Scottish Legionella Reference Laboratory, Stobhill Hospital, Glasgow, Scotland,5 Istituto Cantonale Batteriologico, Lugano, Switzerland,6 Respiratory and Systemic Infection Laboratory, PHLS Central Public Health Laboratory, London, United Kingdom7

Received 29 July 2002/ Accepted 17 November 2002

The clinical utility of Legionella urinary antigen assays for the diagnosis of Legionnaires' disease was assessed by using samples from 317 culture-proven cases. The sensitivities of the Binax enzyme immunoassay (EIA) and Biotest EIA were found to be 93.7 and 94.4% for travel-associated infection and 86.5 and 76.0% for community-acquired infection but only 44.2 and 45.7% for nosocomially acquired infection, respectively.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Hygiene, Medical Faculty of the Technical University Dresden, Fetscherstr. 74, D-01307 Dresden, Germany. Phone: 49-351-458-6577. Fax: 49-351-4586310. E-mail: Juergen.Helbig{at}mailbox.tu-dresden.de.

Journal of Clinical Microbiology, February 2003, p. 838-840, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.838-840.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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