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Journal of Clinical Microbiology, February 2003, p. 860-862, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.860-862.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Russia

Lyudmila Yashina,1 Oleg Vyshemirskii,2 Sergei Seregin,1 Irina Petrova,1 Evgeny Samokhvalov,2 Dmitry Lvov,2 Valery Gutorov,1 Irina Kuzina,1 Georgy Tyunnikov,1 Yi-Wei Tang,3 Sergei Netesov,1 and Vladimir Petrov1*

State Research Center of Virology and Biotechnology "Vector," Koltsovo, Novosibirsk Region, 630559,1 Ivanovsky Institute of Virology, RAMS, Moscow, 123098, Russia,2 Vanderbilt University Medical Center, Nashville, Tennessee 37232-26053

Received 17 July 2002/ Accepted 4 October 2002

Genetic analysis of wild-type Crimean-Congo hemorrhagic fever (CCHF) virus strains recovered in the European part of Russia was performed. Reverse transcriptase PCR followed by direct sequencing was used to recover partial sequences of the CCHF virus medium (M) genome segment (M segment) from four pools of Hyalomma marginatum ticks and six human patients. Phylogenetic analysis of the M-segment sequences from Russian strains revealed a close relatedness of the strains (nucleotide sequence diversity, <=5.0%). The strains differed significantly from CCHF viruses from other regions of the world (nucleotide sequence diversity, 10.3 to 20.4%), suggesting that CCHF virus strains recovered in the European part of Russia form a distinct group.

* Corresponding author. Mailing address: State Research Center of Virology and Biotechnology "Vector," Koltsovo, Novosibirsk Region, 630559, Russia. Phone: 7 (383-2) 36-74-39. Fax: 7 (383-2) 36-74-09. E-mail: petrovvs{at}vector.nsc.ru.

Journal of Clinical Microbiology, February 2003, p. 860-862, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.860-862.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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