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Journal of Clinical Microbiology, March 2003, p. 1277-1279, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1277-1279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Hepatitis B Virus Genotype C Takes a More Aggressive Disease Course Than Hepatitis B Virus Genotype B in Hepatitis B e Antigen-Positive Patients

Henry Lik-Yuen Chan,* May Ling Wong, Alex Yui Hui, Lawrence Cheung-Tsui Hung, Francis Ka-Leung Chan, and Joseph Jao-Yiu Sung

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China

Received 1 July 2002/ Returned for modification 28 September 2002/ Accepted 8 December 2002

One hundred forty-six hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients were followed up for 32 ± 13 months. All six patients with hepatocellular carcinoma had hepatitis B virus (HBV) genotype C. Disease activity was greater in patients infected by HBV genotype C than in those infected by HBV genotype B in the HBeAg-positive phase but not after HBeAg seroconversion.

* Corresponding author. Present address: Department of Medicine and Therapeutics, 9/F Prince of Wales Hospital, Shatin, New Territories, Hong Kong. Phone: 852-2632-3616. Fax: 852-2637-5396. E-mail: hlychan{at}hotmail.com.

Journal of Clinical Microbiology, March 2003, p. 1277-1279, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1277-1279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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