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Journal of Clinical Microbiology, March 2003, p. 1316-1321, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1316-1321.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Stability of Allelic Frequencies and Distributions of Candida albicans Microsatellite Loci from U.S. Population-Based Surveillance Isolates

Timothy J. Lott,1* Ruth E. Fundyga,1 Mary E. Brandt,1 Lee H. Harrison,2,3 Andre N. Sofair,4 Rana A. Hajjeh,1 and David W. Warnock1

Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,1 Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland,2 University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania ,3 Yale University School of Medicine, New Haven, Connecticut4

Received 22 October 2002/ Returned for modification 27 November 2002/ Accepted 15 December 2002

Allelic distributions and frequencies of five Candida albicans microsatellite loci have been determined for strains isolated from the bloodstream and obtained through active population-based surveillance in two U.S. metropolitan areas between 1998 and 2000. These data were compared to data for isolates obtained from two other U.S. regions in 1992 to 1993. In a majority of pairwise combinations between sites, no evidence was seen for shifts in microsatellite allelic frequencies. One to three alleles were highly predominant and correlated with major genotypes. These data both support the concepts of allelic stability and genetic equilibria and suggest that, in the United States, strains of C. albicans isolated from the bloodstream may form a defined, genetically homogeneous population across geographical distance and time.

* Corresponding author. Mailing address: Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., N.E., Mailstop G-11, Atlanta, GA 30333. Phone: (404) 639-2459. Fax: (404) 639-3546. E-mail: tjl1{at}cdc.gov.

Journal of Clinical Microbiology, March 2003, p. 1316-1321, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1316-1321.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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