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Journal of Clinical Microbiology, April 2003, p. 1712-1716, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1712-1716.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Distinctiveness of Mycobacterium tuberculosis Genotypes from Human Immunodeficiency Virus Type 1-Seropositive and -Seronegative Patients in Lima, Peru

Niyaz Ahmed,1 Luz Caviedes,2 Mahfooz Alam,1 K. Rajender Rao,1 Vartul Sangal,1 Patricia Sheen,2 Robert H. Gilman,2,3,4 and Seyed E. Hasnain1,5,6*

Centre for DNA Fingerprinting and Diagnostics (CDFD), Nacharam, Hyderabad 500076,1 National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi,5 Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India,6 Department of Pathology, Universidad Peruana Cayetano Heredia,2 Asociación Benefica Proyectos en Informatica, Salud, Medicina y Agricultura (AB PRISMA), Lima, Peru,3 Johns Hopkins School of Public Health and Hygiene, Baltimore, Maryland4

Received 20 September 2002/ Returned for modification 16 November 2002/ Accepted 18 January 2003

Genotypic analysis of Mycobacterium tuberculosis isolates obtained from human immunodeficiency virus type 1 (HIV-1)-seropositive (n = 80) and -seronegative (n = 25) patients from Lima, Peru, revealed two distinct genotypes correlating with the host immune status. While the level of intrastrain diversity of DNA fingerprints of HIV-seropositive isolates was less pronounced, these isolates showed many clonal groupings.

* Corresponding author. Mailing address: Centre for DNA Fingerprinting and Diagnostics (CDFD), Ecil Rd., Nacharam, Hyderabad 500076, India. Phone: 91 40 27155604. Fax: 91 40 27155610. E-mail: director{at}cdfd.org.in.

Journal of Clinical Microbiology, April 2003, p. 1712-1716, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1712-1716.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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