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Journal of Clinical Microbiology, April 2003, p. 1769-1771, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1769-1771.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clonal Dissemination of Yersinia enterocolitica Strains with Various Susceptibilities to Nalidixic Acid

Javier Sánchez-Céspedes,1 Margarita M. Navia,1 Rocío Martínez,2 Beatriz Orden,2 Rosario Millán,2 Joaquín Ruiz,1 and Jordi Vila1*

Servei de Microbiologia, Institut Clínic Infeccions i Immunología, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona,1 C. E. Argüelles Microbiology Laboratory, Hospital Universitario Puerta de Hierro, 28008 Madrid, Spain2

Received 13 September 2002/ Returned for modification 18 October 2002/ Accepted 7 January 2003

Ten epidemiologically related Yersinia enterocolitica clinical isolates were studied. Six isolates were nalidixic acid resistant (MIC > 512 µg/ml), with mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene, suggesting clonal dissemination of a nalidixic acid-susceptible Y. enterocolitica strain which has acquired different mutations generating resistance to nalidixic acid.

* Corresponding author. Mailing address: Department of Microbiology, Hospital Clínic, Facultad de Medicina, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain. Phone: 34.93.2275522. Fax: 34.93.2275454. E-mail: vila{at}medicina.ub.es.

Journal of Clinical Microbiology, April 2003, p. 1769-1771, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1769-1771.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • Capilla, S., Ruiz, J., Goni, P., Castillo, J., Rubio, M. C., Jimenez de Anta, M. T., Gomez-Lus, R., Vila, J. (2004). Characterization of the molecular mechanisms of quinolone resistance in Yersinia enterocolitica O:3 clinical isolates. J Antimicrob Chemother 53: 1068-1071 [Abstract] [Full Text]  
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