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Journal of Clinical Microbiology, April 2003, p. 1772-1774, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1772-1774.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Prenatal Diagnosis of Congenital Human Cytomegalovirus Infection in Amniotic Fluid by Nucleic Acid Sequence-Based Amplification Assay

M. Grazia Revello,1 Daniele Lilleri,1 Maurizio Zavattoni,1 Milena Furione,1 Jaap Middeldorp,2 and Giuseppe Gerna1*

Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy,1 Free University of Amsterdam, Amsterdam, The Netherlands2

Received 21 October 2002/ Returned for modification 15 November 2002/ Accepted 15 December 2002

Nucleic acid sequence-based amplification assays for detection of human cytomegalovirus (HCMV) immediate-early and pp67 mRNA in 65 amniotic fluid samples tested for prenatal diagnosis of congenital HCMV infection showed sensitivity, specificity, and negative and positive predictive values >90%.

* Corresponding author. Mailing address: Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy. Phone: 39 0382 502644. Fax: 39 0382 502599. E-mail: g.gerna{at}smatteo.pv.it.

Journal of Clinical Microbiology, April 2003, p. 1772-1774, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1772-1774.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • VIRREIRA, M., MARTINEZ, S., ALONSO-VEGA, C., TORRICO, F., SOLANO, M., TORRICO, M. C., PARRADO, R., TRUYENS, C., CARLIER, Y., SVOBODA, M. (2006). AMNIOTIC FLUID IS NOT USEFUL FOR DIAGNOSIS OF CONGENITAL TRYPANOSOMA CRUZI INFECTION. Am J Trop Med Hyg 75: 1082-1084 [Abstract] [Full Text]  


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