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Journal of Clinical Microbiology, April 2003, p. 1775-1778, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1775-1778.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Distribution of the saa Gene in Strains of Shiga Toxin-Producing Escherichia coli of Human and Bovine Origins

Claire Jenkins,1,2* Neil T. Perry,1 Tom Cheasty,1 Darren J. Shaw,3 Gad Frankel,2 Gordon Dougan,2 George J. Gunn,4 Henry R. Smith,1 Adrienne W. Paton,5 and James C. Paton5

Laboratory of Enteric Pathogens, Central Public Health Laboratory, London NW9 5HT,1 Centre for Molecular Microbiology and Immunology, Imperial College, London SW7 2AZ,2 Centre for Tropical and Veterinary Medicine, University of Edinburgh, Roslin, Midlothian EH25 9RG,3 Scottish Agricultural College, Drummondhill, Inverness IV2 4JZ, United Kingdom,4 Department of Molecular Biosciences, University of Adelaide, Adelaide, South Australia 5005, Australia5

Received 8 November 2002/ Accepted 7 January 2003

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P < 0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

* Corresponding author. Mailing address: Laboratory of Enteric Pathogens, Central Public Health Laboratory, 61 Colindale Ave., London NW9 5HT, United Kingdom. Phone: 44 020 8200 4400. Fax: 44 020 8905 9929. E-mail: cjenkins{at}phls.org.uk.

Journal of Clinical Microbiology, April 2003, p. 1775-1778, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1775-1778.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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