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Journal of Clinical Microbiology, May 2003, p. 2144-2146, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2144-2146.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Kinetics and Significance of Serum Hepatitis C Virus Core Antigen in Patients with Acute Hepatitis C

Agostino Cividini,1,2 Antonella Cerino,1 Alba Muzzi,2 Milena Furione,3 Chiara Rebucci,2 Laura Segagni,1 Marta Gatti,3 Vincenzo Barnaba,4 and Mario U. Mondelli1,2*

Laboratori di Ricerca-Area Infettivologica,1 Dipartimento di Malattie Infettive,2 Servizio di Virologia, IRCCS Policlinico, San Matteo, and University of Pavia, Pavia,3 Laboratorio di Immunologia Cellulare e Molecolare, Fondazione A. Cesalpino, Policlinico Umberto I, and University of Roma "La Sapienza," Rome, Italy4

Received 16 September 2002/ Returned for modification 8 December 2002/ Accepted 17 February 2003

An immunoassay detecting hepatitis C virus core antigen was evaluated for its ability to predict clinical outcome in a series of patients with acute hepatitis C. In subjects who cleared the virus, core antigen was no longer detectable within 16 weeks of onset, whereas considerable fluctuations were noted among patients progressing to chronic hepatitis, one of whom showed consistently negative values despite the intermittent presence of viral RNA.

* Corresponding author. Mailing address: Laboratori di Ricerca-Area Infettivologica, IRCCS Policlinico San Matteo, via Taramelli 5, 27100 Pavia, Italy. Phone: 39-0382-502636. Fax: 39-0382-526450. E-mail: m.mondelli{at}smatteo.pv.it.

Journal of Clinical Microbiology, May 2003, p. 2144-2146, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2144-2146.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Takahashi, M., Saito, H., Higashimoto, M., Atsukawa, K., Ishii, H. (2005). Benefit of Hepatitis C Virus Core Antigen Assay in Prediction of Therapeutic Response to Interferon and Ribavirin Combination Therapy. J. Clin. Microbiol. 43: 186-191 [Abstract] [Full Text]  
  • Krajden, M., Shivji, R., Gunadasa, K., Mak, A., McNabb, G., Friesenhahn, M., Hendricks, D., Comanor, L. (2004). Evaluation of the Core Antigen Assay as a Second-Line Supplemental Test for Diagnosis of Active Hepatitis C Virus Infection. J. Clin. Microbiol. 42: 4054-4059 [Abstract] [Full Text]  
  • Rebucci, C., Cerino, A., Cividini, A., Timo, L., Furione, M., Mondelli, M. U. (2003). Monitoring Response to Antiviral Therapy for Patients with Chronic Hepatitis C Virus Infection by a Core-Antigen Assay. J. Clin. Microbiol. 41: 3881-3884 [Abstract] [Full Text]  


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