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Journal of Clinical Microbiology, May 2003, p. 2184-2186, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2184-2186.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Detection of Circulating Aspergillus fumigatus Galactomannan: Value and Limits of the Platelia Test for Diagnosing Invasive Aspergillosis

Claudine Pinel,1* Hélène Fricker-Hidalgo,1 Bernadette Lebeau,1 Frédéric Garban,2 Rébecca Hamidfar,3 Pierre Ambroise-Thomas,1 and Renée Grillot1

Service de Parasitologie-Mycologie,1 Département de Cancérologie,2 Département de Médecine Aïgue Spécialisée, Centre Hospitalier Universitaire, 38043 Grenoble, France3

Received 5 August 2002/ Returned for modification 3 September 2002/ Accepted 1 February 2003

The effectiveness of galactomannan detection with the Platelia test was evaluated in a prospective study of 3,327 sera from 807 patients. The specificity was 99.6% (748 of 751 cases). For the groups of patients with proven and probable invasive aspergillosis, the sensitivity was 50.0% (17 of 34 cases). The disappointing sensitivity associated with the presence of rare false-positive cases underlines the limits of this test.

* Corresponding author. Mailing address: Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 38043 Grenoble, France. Phone: (33) 476765490. Fax: (33) 476765660. E-mail: CPinel{at}chu-grenoble.fr.

Journal of Clinical Microbiology, May 2003, p. 2184-2186, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2184-2186.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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