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Journal of Clinical Microbiology, June 2003, p. 2706-2708, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2706-2708.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular and Conventional Epidemiology of Tuberculosis in Hong Kong: a Population-Based Prospective Study

Moira Chan-Yeung,1* Cheuk-Ming Tam,2 Harriet Wong,1 Chi-Chiu Leung,2 Julie Wang,1 Wing-Wai Yew,3 Chak-Wah Lam,4 and Kai-Man Kam5

Hong Kong Government Tuberculosis and Chest Service,2 Tuberculosis Reference Laboratory, Public Health Laboratory Centre, Department of Health,5 Division of Respiratory and Critical Care Medicine, Department of Medicine, The University of Hong Kong,1 Tuberculosis and Chest Unit, Grantham Hospital,3 Ruttonjee and Tang Shiu Kin Hospital, Hong Kong, Special Administrative Region, People’s Republic of China4

Received 12 November 2002/ Returned for modification 16 January 2003/ Accepted 24 February 2003

A prospective population-based molecular and conventional epidemiological study of 65.4% of bacteriologically confirmed cases of tuberculosis was carried out on the island of Hong Kong from May 1999 to Oct 2000 by the IS6110-based restriction fragment length polymorphism technique. Eleven of the isolates had five or fewer bands; 24.5% of the remaining 691 isolates belonged to clusters. The estimated proportion of recently transmitted disease was 15 to 20%.

* Corresponding author. Mailing address: 4/F, Professorial Block, Queen Mary Hospital, 102 Pokfulam Rd., Hong Kong. Phone: 852-2855-4385. Fax: 852-2855-1143. E-mail: mmwchan{at}hkucc.hku.hk.

Journal of Clinical Microbiology, June 2003, p. 2706-2708, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2706-2708.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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