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Journal of Clinical Microbiology, June 2003, p. 2741-2743, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2741-2743.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interpreting the Results of the Amplified Mycobacterium tuberculosis Direct Test for Detection of M. tuberculosis rRNA

Andrew M. Middleton,1 Paul Cullinan,2 Robert Wilson,3 Jonathan R. Kerr,1 and Maureen V. Chadwick1*

Department of Microbiology,1 Host Defence Unit, Royal Brompton and Harefield Hospitals NHS Trust,3 Department of Occupational and Environmental Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom2

Received 29 July 2002/ Returned for modification 21 January 2003/ Accepted 4 March 2003

The Amplified Mycobacterium tuberculosis Direct (AMTD) test detects M. tuberculosis rRNA. By using culture of M. tuberculosis as a gold standard, a number of different diagnostic indices were examined in an attempt to determine the diagnostic performance of the AMTD test and demonstrate how it might usefully be interpreted during the early management of disease.


* Corresponding author. Mailing address: Department of Microbiology, Royal Brompton and Harefield Hospitals NHS Trust, Sydney St., London SW3 6NP, United Kingdom. Phone: 44-207-3518446. Fax: 44-207-3518443. E-mail: m.chadwick{at}rbh.nthames.nhs.uk.


Journal of Clinical Microbiology, June 2003, p. 2741-2743, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2741-2743.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.




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